When you do have symptoms, they may include: Weakness or fatigue. Bruising or bleeding easily. Fever or chills. Infections that are severe or keep coming back. Pain in your bones or joints. Headaches. Vomiting. Seizures. Weight loss. Night sweats. Oct 17, · Cancers (including ALL) can be caused by mutations (changes) that turn on oncogenes or turn off tumor suppressor genes. These types of changes can stop bone .